期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 142, 期 3-4, 页码 219-227出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2011.05.019
关键词
Chicken; Genetic lines; Heterophil function; beta-Glucan; Ascorbic acid; Corticosterone
资金
- National Research Initiative through USDA National Institute of Food and Agriculture (NIFA) [2007-35604-17866]
- USDA [2005-38420-15810]
- Royal Thai Government
- Iowa State University Center for Integrated Animal Genomics
The effect of dietary supplementation of immunomodulators on in vitro chicken heterophil function was investigated using three diverse genetic lines of chickens (broiler, Fayoumi, and Leghorn). Dietary supplementation with beta-glucan, ascorbic acid, and corticosterone was fed from 8 to 11 weeks of age. Heterophil function was evaluated weekly during supplementation using phagocytosis, bacterial killing, and heterophil extracellular traps (HETs)-DNA release. Fayoumis fed the basal diet had significantly higher HETs-DNA release (P=0.002) than Leghorns and broilers. Both genetic line and immunomodulator diet supplementation had significant effects on bacterial killing (line and diet effect: P<0.001) and HETs-DNA release (line: P<0.001; diet: P=0.043). Dietary supplementation with immunomodulators, therefore, shows potential to affect and augment heterophil function in chickens. The current results also suggest the important role of genetics in innate immune responses. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据