期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 133, 期 2-4, 页码 309-313出版社
ELSEVIER
DOI: 10.1016/j.vetimm.2009.08.008
关键词
IL-17; IL-23; Cytokines; T cells; Equine; Th17; Th2
资金
- NRI-USDA [2006-35204-16880]
This report describes the initial cloning and characterization of the equine interleukin-17 (IL-17) expressed gene sequence from mRNA obtained from equine intestinal tissue and interleukin-23 (IL-23) expressed gene sequence from mRNA obtained from equine peripheral blood mononuclear cells. Equine IL-17 has 462 nucleotides in the translated region, determined by homology with known human and mouse sequences, and shares 84% and 75% identity, respectively. For the deduced amino acid sequences, the identity with human and mouse is 76% and 70%. Equine IL-23 has 579 nucleotides in the translated region. Homology with known human and mouse sequences was determined to be 89% and 77%. Deduced amino acid identities are 89% with the human sequence and 70% with the mouse sequence. The gene sequences were identified as part of the U.S. Veterinary Immune Reagent Network with a goal of developing reagents in order to aid veterinary researchers in the investigation of diseases in livestock species. (C) 2009 Published by Elsevier B.V.
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