期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 134, 期 1-2, 页码 90-95出版社
ELSEVIER
DOI: 10.1016/j.vetimm.2009.10.014
关键词
FIV; Pallas' cat; Evolution; Histopathology; Felidae
资金
- Intramural NIH HHS [Z01 BC010537-06] Funding Source: Medline
- NCI NIH HHS [N01CO12400, N01-CO-12400] Funding Source: Medline
Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host. (C) 2009 Elsevier B.V. All rights reserved.
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