期刊
VETERINARY DERMATOLOGY
卷 25, 期 6, 页码 512-U43出版社
WILEY-BLACKWELL
DOI: 10.1111/vde.12166
关键词
-
资金
- Pfizer Animal Health, New York, NY, USA
Background Oral glucocorticoids are widely used to reduce pruritus and dermatitis associated with allergic dermatitis. Data suggest that oclacitinib, a Janus kinase inhibitor, is a safe and effective alternative. Hypothesis/Objectives To evaluate the efficacy and safety of oclacitinib compared with prednisolone for the control of pruritus associated with allergic dermatitis in a single-masked, controlled clinical trial with a randomized complete block design. Animals Client-owned dogs (n=123) with a presumptive diagnosis of allergic dermatitis and moderate to severe pruritus as assessed by the pet owner were enrolled. Methods Dogs were randomized to treatment with either oclacitinib (0.4-0.6mg/kg orally twice daily for 14days, then once daily) or prednisolone (0.5-1.0mg/kg once daily for 6days, then every other day) for 28days. An enhanced visual analog scale (VAS) was used by owners to assess pruritus and by veterinarians to assess dermatitis, at all time points assessed. Results Both treatments produced a rapid onset of efficacy within 4h. The mean reductions in pruritus and dermatitis scores were not significantly different between the treatments except on day14, when reductions were more pronounced for oclacitinib than prednisolone (P=0.0193 for owner pruritus scores; P=0.0252 for veterinarian dermatitis scores). Adverse events were reported with similar frequency in both groups. Conclusion and clinical importance In this study, both oclacitinib and prednisolone provided rapid, effective and safe control of pruritus associated with allergic dermatitis, with substantial improvement in pruritus, reported by owners, and dermatitis, reported by veterinarians.
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