期刊
VECTOR-BORNE AND ZOONOTIC DISEASES
卷 14, 期 12, 页码 862-865出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vbz.2014.1607
关键词
Central Africa; Aedes africanus; Zika virus; Genomic characterization; Aedes opok
资金
- Programme Transversal de Recherche CEVACAR - Institut Pasteur (Paris, France) [385]
Zika virus (ZIKV) is an emerging pathogen belonging to the Spondweni serocomplex within the genus Flavivirus. It has been isolated from several mosquito species. Two lineages of ZIKV have been defined by polyprotein homology. Using high-throughput sequencing, we obtained and characterized three complete genomes of ZIKV isolated between 1976 and 1980 in the Central African Republic. The three viruses were isolated from two species of mosquito, Aedes africanus and Ae. opok. Two sequences from Ae. africanus had 99.9% nucleotide sequence identity and 100% amino acid identity, whereas the complete genome obtained from Ae. opok had 98.3% nucleotide identity and 99.4% amino acid identity with the other two genomes. Phylogenetic analysis based on the amino acid sequence of the polyprotein showed that the three ZIKV strains clustered together but diverged from all other ZIKV strains. Our molecular data suggest that a different subtype of West African ZIKV strains circulated in Aedes species in Central Africa.
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