期刊
VECTOR-BORNE AND ZOONOTIC DISEASES
卷 13, 期 6, 页码 401-405出版社
MARY ANN LIEBERT INC
DOI: 10.1089/vbz.2012.1097
关键词
Surveillance; West Nile virus; Dead birds; Chronic infections; Overwintering
资金
- Extended Laboratory Capacity funds from the Centers for Disease Control and Prevention
- National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [AI55607]
- Research and Policy in Infectious Disease Dynamics (RAPIDD) Program, Fogarty Center, NIH
- Department of Homeland Security
During 2010 and 2011, 933 recently deceased birds, submitted as part of the dead bird surveillance program, tested positive for West Nile virus RNA at necropsy. The relative amount of RNA measured by qRT-PCR cycles ranged from 8.2 to 37.0 cycle threshold (Ct) and formed a bimodal frequency distribution, with maxima at 20 and 36 Ct and minima at 28-30 Ct. On the basis of frequency distributions among different avian species with different responses to infection following experimental inoculation, field serological data indicating survival of infection, and the discovery of persistent RNA in experimentally infected birds, dead birds collected in nature were scored as recent or chronic infections on the basis of Ct scores. The percentage of birds scored as having chronic infections was highest during late winter/spring, when all birds were after hatching year, and lowest during late summer, when enzootic transmission was typically highest as indicated by mosquito infections. Our data indicated that intervention efforts should not be based on dead birds with chronic infections unless supported by additional surveillance metrics.
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