期刊
VASCULAR PHARMACOLOGY
卷 63, 期 3, 页码 105-113出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2014.09.002
关键词
Nitroglycerin; Isosorbide mono- and dinitrate; Pentaerythrityl tetranitrate; Tolerance; Endothelin
资金
- Stiftung Mainzer Herz
- Robert Muller Stiftung
- Center for Translational Vascular Biology (CTVB)
Given acutely, organic nitrates, such as nitroglycerin (GTN), isosorbide mono- and dinitrates (ISMN, ISDN), and pentaerythrityl tetranitrate (PETN), have potent vasodilator and anti-ischemic effects in patients with acute coronary syndromes, acute and chronic congestive heart failure and arterial hypertension. During long-term treatment, however, side effects such as nitrate tolerance and endothelial dysfunction occur, and therapeutic efficacy of these drugs rapidly vanishes. Recent experimental and clinical studies have revealed that organic nitrates per se are not just nitric oxide (NO) donors, but rather a quite heterogeneous group of drugs considerably differing for mechanisms underlying vasodilation and the development of endothelial dysfunction and tolerance. Based on this, we propose that the term nitrate tolerance should be avoided and more specifically the terms of GTN, ISMN and ISDN tolerance should be used. The present review summarizes preclinical and clinical data concerning organic nitrates. Here we also emphasize the consequences of chronic nitrate therapy on the supersensitivity of the vasculature to vasoconstriction and on the increased autocrine expression of endothelin. We believe that these so far rather neglected and underestimated side effects of chronic therapy with at least GTN and ISMN are clinically important. (C) 2014 Elsevier Inc. All rights reserved.
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