期刊
VASCULAR PHARMACOLOGY
卷 49, 期 4-6, 页码 151-157出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2008.05.004
关键词
Diabetes; FPTIII; Vascular dysfunction; Ischemia; Carotid artery
We studied the effect an inhibitor of Ras-GTPase (FPTIII, 1.5 mg/kg alt diem for 4 weeks) on mean arterial pressure (MAP), urine protein, vascular reactivity and cardiac function in streptozotocin (STZ)-induced diabetes in control normotensive (WKY) and spontaneously hypertensive rats (SHR). The increased urinary protein in STZ-treated WKY (D-WKY) and STZ-treated SHR (D-SHR) were significantly lower in FPTIII treated D-WKY and D-SHR. The abnormal Vascular responsiveness to endothelin-1, angiotensin 11, carbachol or histamine in isolated carotid artery from D-WKY and D-SHR was improved by chronic treatment with FPTIII. In isolated perfused hearts, recovery of left ventricular function from 40 min of global ischemia was significantly improved in FPTIII treated D-WKY and D-SHR. These results show that treatment with FPTIII can attenuate development of abnormal vascular reactivity and renal/cardiac dysfunction during simultaneous occurrence of hypertension and diabetes. (C) 2008 Elsevier Inc. All rights reserved.
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