期刊
VASCULAR MEDICINE
卷 19, 期 5, 页码 394-406出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1358863X14550542
关键词
Atherosclerosis; co-culture; macrophage; smooth muscle cell; inflammation
资金
- U.S. Department of Veterans Affairs [I01BX001398]
- National Institutes of Health [NHLBI 1T32HL098049]
Atherosclerotic cardiovascular disease has been acknowledged as a chronic inflammatory condition. Monocytes and macrophages lead the inflammatory pathology of atherosclerosis whereas changes in atheromatous plaque thickness and matrix composition are attributed to vascular smooth muscle cells. Because these cell types are key players in atherosclerosis progression, it is crucial to utilize a reliable system to investigate their interaction. In vitro co-culture systems are useful platforms to study specific molecular mechanisms between cells. This review aims to summarize the various co-culture models that have been developed to investigate vascular smooth muscle cell and monocyte/macrophage interactions, focusing on the monocyte/macrophage effects on vascular smooth muscle cell function.
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