期刊
VACCINE
卷 32, 期 22, 页码 2623-2630出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2014.03.020
关键词
ADCI; GLURP; Pfs48/45; Plasmodium falciparum; SMFA; transmission blocking
资金
- Seventh Framework Program Theme Health-2009-2.3.2-5 [242079]
- Proof of Concept funding
- Ministry of Science, Innovation and Higher Education, Denmark
Effective control and eventual eradication of malaria drives the imperative need for clinical development of a malaria vaccine. Asexual parasite forms are responsible for clinical disease and death while apathogenic gametocytes are responsible for transmission from man to mosquito. Vaccines that combine antigens from both stages may provide direct protection and indirect benefit by reducing the force of infection. We constructed a chimeric antigen composed of a fragment of the Plasmodium falciparum (PP glutamate-rich protein fused in frame to a correctly folded fragment of Pfs48/45. The chimera was produced in Lactococcus lactis and induced robust antibody responses in rodents to the individual components. Specific antibodies showed strong transmission blocking activity against multiple Pf-strains in the standard membrane feeding assay and functional activity against asexual stages in the antibody dependent cellular inhibition assay. The combined data provide a strong rationale for entering the next phase of clinical grade production and testing. (C) 2014 Elsevier Ltd. All rights reserved.
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