期刊
VACCINE
卷 32, 期 21, 页码 2406-2412出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2014.03.012
关键词
Enterovirus 71; Coxsackievirus A 16; Bivalent vaccine; Neutralizing antibody; Passive protection
资金
- National Natural Science Foundation of China [31370930]
- Science and Technology Commission of Shanghai Municipality [13431900601]
- Shanghai Pasteur Foundation
- Chinese Academy of Sciences [KSCX2-YW-BR-2, KSCX2-EW-R-17]
- Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- SA-SIBS scholarship program
Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand, foot and mouth disease (HFMD), which is an infectious disease frequently occurring in children. A bivalent vaccine against both EV71 and CA16 is highly desirable. In the present study, we compare monovalent inactivated EV71, monovalent inactivated CA16, and a combination vaccine candidate comprising of both inactivated EV71 and CA16, for their immunogenicity and in vivo protective efficacy. The two monovalent vaccines were found to elicit serum antibodies that potently neutralized the homologous virus but had no or weak neutralization activity against the heterologous one; in contrast, the bivalent vaccine immunized sera efficiently neutralized both EV71 and CA16. More importantly, passive immunization with the bivalent vaccine protected mice against either EV71 or CA16 lethal infections, whereas the monovalent vaccines only prevented the homologous but not the heterologous challenges. Together, our results demonstrate that the experimental bivalent vaccine comprising of inactivated EV71 and CA16 induces a balanced protective immunity against both EV71 and CM 6, and thus provide proof-of-concept for further development of multivalent vaccines for broad protection against HFMD. (C) 2014 Elsevier Ltd. All rights reserved.
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