期刊
VACCINE
卷 30, 期 13, 页码 2245-2249出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2012.01.065
关键词
Clostridium difficile; Vaccine; Safety; Immunogenicity; Dose finding
资金
- Acambis, Inc.
Fifty healthy adult (18-55 years) and 48 elderly (>= 65 years) volunteers were randomized to receive a candidate Clostridium difficile toxoid vaccine (2 mu g, 10 mu g, or 50 mu g) or placebo on Days 0,28, and 56. No volunteer receiving placebo seroconverted. For toxin A, seroconversion by Day 56 (post-dose 2) was observed in 100% of volunteers aged 18-55 years in all dose groups and in 50%, 89%, and 100% of elderly participants in the 2 mu g, 10 mu g, and 50 mu g dose groups, respectively. For both age groups, seroconversion for toxin 8 was lower than toxin A. There were no safety concerns. (C) 2012 Elsevier Ltd. All rights reserved.
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