期刊
VACCINE
卷 30, 期 19, 页码 2918-2920出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.12.028
关键词
Rabies pre-exposure vaccination; Single dose; 4-Sites ID booster; Tissue culture rabies vaccine
资金
- Queen Saovabha Memorial Institute, the Thai Red Cross Society
We performed an abbreviated prospective study of rabies pre-exposure (PREP) vaccination in 109 volunteers. Group 1, the control group, received the conventional 3 intradermal injections on days 0, 7 and 21. Group 2 received one rabies vaccine injection (0.1 ml intradermally) at 2 sites on a single day. Group 3 was given one full ampule intramuscularly. One year later, all 3 groups received booster injections (0.1 ml at 4 sites) intradermally at one time or 2 injections intramuscularly on days 0 and 3. All subjects achieved a vigorous anamnestic antibody response 7 days after the boosters. These data suggest that one time immunization of one full dose intramuscularly or 2 site injections of 0.1 intradermally on a single day are adequate to prime immune memory and obtain an accelerated immune response one year later. (C) 2011 Elsevier Ltd. All rights reserved.
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