期刊
VACCINE
卷 29, 期 17, 页码 3284-3292出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.02.022
关键词
Malaria vaccine candidate; Toll-like receptor agonist; Long-lived plasma cell
资金
- European Commission [LSHP-CT-2007-037506]
- EMVI, the Lund-beck Foundation
- Fonden til Laegevidenskabens fremme
- Bill and the Melinda Gates Foundation [42387]
GMZ2 adjuvanted by aluminum hydroxide is a candidate malaria vaccine that has successfully passed phase 1 clinical testing in adult German and Gabonese volunteers and Gabonese children under five. Here we report a preclinical study screening a series of adjuvant vehicles and Toll-like receptor (TLR) agonists in CB6F1 mice to identify an improved formulation of GMZ2 suitable for further human clinical studies. GMZ2 formulated in an oil-in-water emulsion plus the synthetic TLR4 agonist CIA elicits the highest (a) vaccine-specific IgG2a and total IgG titers, (b) parasite-specific IFA titers, (c) levels of Type I cytokine responses (IFN-gamma), and (d) number of long-lived-plasma cells (LLPC) secreting antibodies against both the GMZ2 fusion and its two components. Thus, CIA helps to elicit a vaccine-specific Type 1 antibody profile together with high levels of LLPC, both of which are thought to be essential for the development of long-term protective immunity against clinical malaria. (C) 2011 Elsevier Ltd. All rights reserved.
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