期刊
VACCINE
卷 29, 期 14, 页码 2519-2522出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.01.074
关键词
Chlamydia; Genital infection; Secondary challenge; Repeated infections; Vaccine; Intranasal; Chlamydial protease-like activity factor; Infertility; Fertility
资金
- National Institutes of Health [1RO1AI074860]
We previously have shown the efficacy of recombinant (r) chlamydial protease-like activity factor (CPAF) vaccination against hydrosalpinx development following primary genital chlamydial challenge. In this study, we evaluated further the protection induced by rCPAF vaccination against infertility. Following primary challenge, fertility levels were not significantly different between the mock- and CPAF-vaccinated and Chlamydia alone challenged mice. However, following secondary genital chlamydial challenge, mock (PBS) immunized mice displayed a significant reduction of fertility compared to age-matched naive mice, while mice vaccinated intranasally with rCPAF+ CpG displayed significant prevention of infertility. These results suggest that hydrosalpinx may be a reliable indicator of impending infertility, and that rCPAF is a promising candidate to prevent infertility resulting from repeated genital chlamydial infections. (C) 2011 Elsevier Ltd. All rights reserved.
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