期刊
VACCINE
卷 29, 期 21, 页码 3773-3781出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.03.031
关键词
Influenza virus; Streptococcus pyogenes; Super-infections; Vaccination
资金
- Office of Research
- USD (VCH)
- USD (MJS and FPD)
- NIH [2 P20 RR016479]
- National Center for Research Resources (LAA)
- Division of Basic Biomedical Sciences, USD
Mortality associated with influenza virus super-infections is frequently due to secondary bacterial complications. To date, super-infections with Streptococcus pyogenes have been studied less extensively than those associated with Streptococcus pneumoniae. This is significant because a vaccine for S. pyogenes is not clinically available, leaving vaccination against influenza virus as our only means for preventing these super-infections. In this study, we directly compared immunity induced by two types of influenza vaccine, either inactivated influenza virus (IIV) or live, attenuated influenza virus (LAIV), for the ability to prevent super-infections. Our data demonstrate that both IIV and LAIV vaccines induce similar levels of serum antibodies, and that LAIV alone induces IgA expression at mucosal surfaces. Upon superinfection, both vaccines have the ability to limit the induction of pro-inflammatory cytokines within the lung, including IFN-gamma which has been shown to contribute to mortality in previous models of superinfection. Limiting expression of these pro-inflammatory cytokines within the lungs subsequently limits recruitment of macrophages and neutrophils to pulmonary surfaces, and ultimately protects both IIV- and LAIV-vaccinated mice from mortality. Despite their overall survival, both IIV- and LAIV-vaccinated mice demonstrated levels of bacteria within the lung tissue that are similar to those seen in unvaccinated mice. Thus, influenza virus:bacteria super-infections can be limited by vaccine-induced immunity against influenza virus, but the ability to prevent morbidity is not complete. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据