期刊
VACCINE
卷 29, 期 43, 页码 7474-7482出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.07.057
关键词
Alzheimer's disease; Immunotherapy; Sendaivirus vector; Amyloid
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [NIBIO 05-27]
- The Meijo Asian Res. Center
- Grant-in-Aid for Explor. Res.
- Grant-in-Aid for Scientific Res.
- JSPS
- Grants-in-Aid for Scientific Research [21390364] Funding Source: KAKEN
Based on the amyloid cascade hypothesis, many reports have indicated that immunotherapy is beneficial for Alzheimer's disease (AD). We developed a mucosal immunotherapy for AD by nasal administration of recombinant Sendai virus vector carrying A beta 1-43 and mouse IL-10 cDNA. Nasal but not intramuscular administration of the vaccine induced good antibody responses to A beta. When APP transgenic mice (Tg2576) received this vaccine once nasally, the A beta plaque burden was significantly decreased 8 weeks after without inducing inflammation in the brain. The amount of A beta measured by ELISA was also reduced in both soluble and insoluble fractions of the brain homogenates, and notably the A beta oligomer (12-mer) was also apparently decreased. Tg2576 mice showed significant improvement in cognitive functions examined at 3 months after vaccination. Thus, this is an alternative immunotherapy for AD, which has an advantage in non-invasive, safe and relatively long lasting features. (C) 2011 Elsevier Ltd. All rights reserved.
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