期刊
VACCINE
卷 29, 期 43, 页码 7514-7522出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.03.083
关键词
Malaria; Vaccine; Heterologous prime-boost
资金
- European Vaccine Initiative (EVI)
We examined the safety, immunogenicity and efficacy of a prime-boost vaccination regime involving two poxvirus malaria subunit vaccines, FP9-PP and MVA-PP, expressing the same polyprotein consisting of six pre-erythrocytic antigens from Plasmodium falciparum. Following safety assessment of single doses, 15 volunteers received a heterologous prime-boost vaccination regime and underwent malaria sporozoite challenge. The vaccines were safe but interferon-gamma ELISPOT responses were low compared to other poxvirus vectors, despite targeting multiple antigens. There was no vaccine efficacy as measured by delay in time to parasitaemia. A number of possible explanations are discussed, including the very large insert size of the polyprotein transgene. (C) 2011 Elsevier Ltd. All rights reserved.
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