期刊
VACCINE
卷 28, 期 36, 页码 5850-5856出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.06.062
关键词
Rabies vaccine; Intradermal; Epidermal
资金
- Becton Dickinson (BD), BD Medical Pharmaceutical Systems and BD Technologies
In the present pilot study, intradermal ID delivery systems with a BD microneedle from 1 to 3 mm in length, and epidermal delivery (BD skin abrader) through abraded skin surface relative to standard intramuscular injection were evaluated. Circulating neutralizing antibodies were measured against the rabies virus after the Vero cells rabies vaccine was administered at DO, D7, D21 and D49. This clinical evaluation in 66 healthy volunteers shows that ID delivery using BD microneedle technology of 1/4 the IM antigen dose is safe, efficient and reliable, resulting in a protective seroconversion rate. In contrast, the epidermal delivery route did not produce an immune response against the rabies vaccine. (C) 2010 Elsevier Ltd. All rights reserved.
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