期刊
VACCINE
卷 28, 期 15, 页码 2693-2699出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.01.053
关键词
Influenza; Vaccine match; WHO recommendations; Antigenic characteristics; Southern Hemisphere; Northern Hemisphere; Seasonality
资金
- Intramural NIH HHS [Z99 TW999999] Funding Source: Medline
In 1999, the World Health Organization switched from annual to semi-annual recommendations for influenza vaccine composition. We compared the antigenic match between recommendations and circulating viruses before and after 1999, in the Northern and Southern Hemispheres. Vaccine match proportion for A/H3N2 viruses increased from 31% to 59% in the Southern Hemisphere (P < 0.05). and is now comparable to that in the Northern Hemisphere. Vaccine match for influenza B decreased from similar to 100% to 33-54% in both hemispheres (P < 0.05), following the unexpected resurgence of influenza B/Victoria in 1997. No estimate was available for influenza A/H1N1. We conclude that semi-annual vaccine recommendations are useful overall and discuss potential ways forward, including a recommendation for the improvement of vaccination policy and influenza surveillance in tropical areas. Published by Elsevier Ltd.
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