期刊
VACCINE
卷 28, 期 35, 页码 5746-5754出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.05.074
关键词
Yersinia pestis Caf1; Alhydrogel; Electron microscopy
资金
- BBSRC
- Avecia Biotechnology and Pharmathene
Caf1 of the plague bacterium, Yersinia pestis is a polymeric virulence factor and vaccine component. formed from monomers by a donor strand exchange (DSE) mechanism. Here. EM images of Caf1 reveal flexible polymers up to 1 5 mu m long (4 MDa). The bead-like structures along the polymer are 58 +/- 1 nm long and correspond to single Caf1 proteins. Short polymers often form circles, presumably by DSE. We also provide the first images of proteins bound to alhydrogel adjuvant. Call, hemocyanin and anthrax PA are all resolved clearly and Caf1 exhibits adjuvant bound stretches with long intervening loops draped from the edges. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据