期刊
VACCINE
卷 29, 期 2, 页码 266-273出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.10.038
关键词
Pandemic influenza H1N1; Vaccine; Healthcare worker
资金
- Influenza Centre, University of Bergen
- Bergen Clinical Vaccine Consortium (BCVC) Innovest, Haukeland University Hospital
- Norwegian Directorate of Health
- Ministry of Health and Care Services
Mass vaccination was the most effective prophylaxis for protecting the population during the influenza H1N1 pandemic. We have evaluated the tolerability, immunogenicity and kinetics of the antibody response to a monovalent oil-in-water (AS03) adjuvanted human pandemic split influenza A/California/7/2009 H1N1 (3.75 mu g haemagglutinin) vaccine in health care workers. Vaccination elicited a rapid and early protective level of haemagglutination inhibition antibody from 6 to 7 days post vaccination, and by 14 to 21 days post vaccination, up to 98% of vaccinees had protective antibody titres which persisted for at least 3 months in 84-92% of subjects. A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic. (C) 2010 Elsevier Ltd. All rights reserved.
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