期刊
VACCINE
卷 28, 期 37, 页码 5960-5966出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.07.002
关键词
Porcine circovirus type 2 (PCV2); Coinfection; Vaccine efficacy; PRRSV; PPV
资金
- National Pork Board Check of Dollars
The efficacies of commercial porcine circovirus type 2 (PCV2) vaccines and a live PCV1-2a chimeric vaccine were compared in conventional, PCV2-positive piglets using a PCV2-porcine reproductive and respiratory syndrome virus (PRRSV)-porcine parvovirus (PPV) coinfection challenge model. Seventy-three, 2-week-old pigs were randomized into seven groups including five vaccinated and two control groups. Pigs in the vaccinated groups were vaccinated at 3 weeks (one dose) or at 3 and 6 weeks (two dose) of age. All vaccine regimens tested were effective in reducing naturally occurring PCV2 viremia at 16 weeks of age and after PCV2 challenge, demonstrating the capability of the products to induce a lasting protective immunity despite the presence of PCV2 viremia at the time of vaccination. (C) 2010 Elsevier Ltd. All rights reserved.
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