期刊
VACCINE
卷 28, 期 41, 页码 6698-6703出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.07.085
关键词
Malaria vaccine; Phase I clinical trial; Malaria immunity
资金
- European Malaria Vaccine Initiative through Directorate General for International Cooperation/Netherlands Ministry of Foreign Affairs - DIGIS
- African Malaria Network Trust (AMANET) through European Commissions
- MRC [G0700837] Funding Source: UKRI
- Medical Research Council [G0700837] Funding Source: researchfish
Malaria is still one of the major public health threats in sub-Saharan Africa. An effective vaccine could be a sustainable control measure that can be integrated into existing health infrastructures. The malaria vaccine candidate GMZ2 is a recombinant fusion protein of conserved parts of Plasmodium falciparum Glutamate Rich Protein and Merozoite Surface Protein 3 adjuvanted with aluminium hydroxide. GMZ2 is immunogenic and well tolerated in malaria-naive adults from Germany. To assess safety and immunogenicity in malaria-exposed individuals, 40 adults from Lambarene. Gabon were randomly assigned to receive either 100 p,g GMZ2 or a rabies control vaccine three times in monthly intervals. Both vaccines were well tolerated. One month after a full course of vaccination, GMZ2-vaccinated individuals had 1.4-fold (95% confidence interval: [1.1, 1.7]) higher baseline-corrected anti-GMZ2 antibody levels and more GMZ2-specific memory B-cells compared to the rabies group (p=0.039), despite a high prevalence of GMZ2-specific immune reactivity due to previous intense exposure to P. falciparum. (C) 2010 Elsevier Ltd. All rights reserved.
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