期刊
VACCINE
卷 28, 期 27, 页码 4348-4355出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.04.055
关键词
Bluetongue; Inactivated vaccines; Cattle and sheep; Long-term efficacy
资金
- CZ Veterinaria S.A., Porrino, Spain
- Fort Dodge Animal Health, Naarden, The Netherlands
- Merial S.A.S., Lyon, France
- German Federal Ministry of Food, Agriculture and Consumer Protection
- EU [FOOD-CT-2006-01 6236]
The long-term efficacy of three commercially available inactivated vaccines against bluetongue virus serotype 8 (BTV-8) (BLUEVAC (R) 8, Zulvac (R) 8, and BTVPUR (R) AlSap 8) was evaluated in a seroprevalence study and challenge experiments. Seroprevalences 1 year after vaccination ranged from 75% to 100%. In two infection experiments, groups of vaccinated sheep and cattle selected either randomly or for low antibody levels were challenged with a European BTV-8 strain 12 months after vaccination. With two exceptions, all animals, including those with low antibody levels prior to challenge, were protected from viral replication and clinical disease even at low initial antibody levels. Vaccination of susceptible ruminants in yearly intervals is thus considered an adequate scheme for BTV-8 control in Europe. (C) 2010 Elsevier Ltd. All rights reserved.
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