期刊
VACCINE
卷 28, 期 16, 页码 2903-2907出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.01.054
关键词
Influenza vaccine; Effectiveness; Case-control studies; Elderly
资金
- European Centre for Disease Prevention and Control
We conducted a case control and screening method studies to estimate influenza vaccine effectiveness (IVE) in the age group >= 65 years, based on the Spanish Influenza Sentinel Surveillance System (SISSS). Cases (influenza laboratory-confirmed) were compared to influenza-negative ILI patients (test-negative) and patients without ILI since the beginning of the season (non-ILI). For the screening method, cases' vaccination coverage was compared to the vaccination coverage of the GPs' catchment population. The results suggested a protective effect of the vaccine against laboratory-confirmed influenza in elderly in 2008-2009. The screening method and the test-negative control designs enable estimating IVE using exclusively SISSS data. (c) 2010 Elsevier Ltd. All rights reserved.
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