EBC-316, 325-327, and 345: New Pimarane Diterpenes from Croton insularis Found in the Australian Rainforest

Five new pimarane and related-type diterpenes (i.e. EBC-316, 325-327, and 345 (10-15)), together with two known pimaranes (EBC-221 (8) and EBC-346 (9)), were isolated from the stems of Croton insularis, found in the Australian rainforest. All pimarane diterpenes disclosed herein are suggested to be biogenetically related to the same keto-Jacobs-Reynolds intermediate 2, via ring A and C oxidation. Anticancer activities of compounds 11-13 are reported.