期刊
VACCINE
卷 27, 期 22, 页码 2981-2988出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.02.105
关键词
Conformationally biased; Response-selective C5a agonists; Molecular adjuvant; Methamphetamine vaccine; Anti-methamphetamine antibodies; Self-administration
Vaccines to methamphetamine (meth) were designed by covalently attaching a meth hapten (METH) to peptide constructs that contained a conformationally biased, response-selective molecular adjuvant, YSFKPMPLaR (EP54). Rats immunized with EP54-containing meth vaccines generated serum antibody titers to authentic meth, an immune outcome that altered meth self-administration. Immunization increased meth self-administration suggesting pharmacokinetic antagonism. The ability of immune sera to bind a METH-modified target protein dramatically decreased during and shortly after the meth self-administration assay, suggesting effective sequestration of free meth. However, the binding ability of immune sera to the METH-modified target protein was recovered 34 days after meth-free clearance time. (C) 2009 Elsevier Ltd. All rights reserved.
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