期刊
VACCINE
卷 27, 期 8, 页码 1230-1241出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.12.004
关键词
Poly(lactic acid); Nanospheres; Strangles; Mucosal vaccine
资金
- Fundacao para a Ciencia e Tecnologia
- Ministerio da Ciencia e da Tecnologia, Portugal [SFRH/BD/14300/2003, POCI/BIO/59147/2004, PPCDT/BIO/59147/2004]
- Fundação para a Ciência e a Tecnologia [POCI/BIO/59147/2004] Funding Source: FCT
Streptococcus equi subspecies equi affects animals of Equidae family and is the causative agent of strangles, an acute, extremely contagious and deadly disease. Prolonged periods of protection associated to absence of serious adverse reactions were not yet achieved. Thus, this experimental work is focused oil the Study of mucosal, humoral and cellular immune responses developed in a mouse model, after the intranasal administration of S. equi antigens associated by adsorption or encapsulation to poly(lactic acid) nanospheres, modified by mucoadhesive polymers and absorption enhancers. Particles fitted the nanometer range and proteins integrity and antigenicity were not affected. PLA nanospheres induced a mixed Th1 and Th2 response, being therefore potential Carriers for the delivery of S. equi antigens. (C) 2008 Elsevier Ltd. All rights reserved.
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