期刊
VACCINE
卷 27, 期 10, 页码 1540-1548出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.01.006
关键词
Cytomegalovirus; Vaccine; T lymphocytes; Cytokines
资金
- Vical Incorporated
CMV-seronegative subjects vaccinated intramuscularly or intradermally with a DNA vaccine encoding pp65. IE1, and gB were administered live-attenuated CMV (Towne) to characterize immune priming by the DNA vaccine. CMV-specific memory T-cells (detected by standard ELISPOT assay in only 20% of subjects) were detected by IFN-gamma cultured ELISPOT assay in 60% of subjects primed intramuscularly and correlated with immune responses after Towne. The median time to first pp65 T-cell and gB antibody response after Towne was 14 days for DNA-primed subjects vs. 28 days for controls administered Towne only (p = 0.02 and 0.03, respectively). Furthermore, there was a trend toward more DNA-vaccinated subjects than controls developing a gB-specific IFN-gamma T-cell response after Towne administration (47% vs. 0%, p = 0.06). (C) 2009 Elsevier Ltd. All rights reserved.
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