期刊
VACCINE
卷 27, 期 43, 页码 6034-6041出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.07.074
关键词
Bordetella pertussis; Pertussis toxin; Pertactin
资金
- Institut Pasteur Foundation [URA CNRS3012]
- GlaxoSmithKIine Biologicals, Rixensart, Belgium
Bordetella pertussis isolates not expressing Pertussis Toxin (PT) or Pertactin (PRN) have been collected, for the first time in 2007, in France, a highly vaccinated country with acellular vaccines. Non-expression was due to deletion of the entire ptx locus, to IS481 insertion in the pm gene or deletion of a part of this gene. Genome sequencing does not indicate any regions of differences when compared to other circulating isolates. It nevertheless shows some sequence differences and an increased number of repeated sequences. The infant infected by the isolate not expressing pertussis toxin, did not present hyperlymphocytosis. All isolates were found less pathogen in animal or cellular models; their circulation raises the problem of clinical and biological diagnoses. (C) 2009 Elsevier Ltd. All rights reserved.
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