期刊
VACCINE
卷 27, 期 30, 页码 4064-4073出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.04.015
关键词
Vaccine; Venezuelan equine encephalitis virus; Animal models
资金
- National Institutes of Health [AI-059491]
- Institute for Human Infections and Immunity at UTMB
Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of alpha beta T cells. Nevertheless, antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4(+) T cells was necessary to prevent lethal encephalitis in mice lacking alpha beta T cell receptor. (C) 2009 Elsevier Ltd. All rights reserved.
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