期刊
VACCINE
卷 27, 期 38, 页码 5247-5251出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.06.062
关键词
Seoul virus; Canine adenovirus type 2; Gn; Mice; Immunity
资金
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0723]
Seoul virus (SEOV), a member of hantavirus genus, is one of the causative agents of hemorrhagic fever with renal syndrome (HFRS) and afflicts tens of thousands of people annually. In this paper, we evaluate the immune response induced by a replication-competent recombinant canine adenovirus type 2 expressing the Gn protein of SEOV (rCAV-2-Gn) in BALB/c mice. Sera from immunized mice contained neutralizing antibodies that could specifically recognize SEOV and neutralize its infectivity in vitro. Moreover, the recombinant virus induced complete protection against a lethal challenge with the highly virulent SEOV strain CC-2. Protective level neutralizing antibodies were maintained for at least 20 weeks. The efficacy of the recombinant was similar to that induced by a currently available inactivated HFRS vaccine. This recombinant virus is therefore a potential alternative to the inactivated vaccine. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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