期刊
VACCINE
卷 27, 期 9, 页码 1333-1339出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.12.059
关键词
Rotavirus; Vaccine; Gastrointestinal disease; Oral poliovirus
Co-administration of oral live-attenuated human rotavirus vaccine RIX4414 (Rotarix (TM)) and oral polio vaccine (OPV) was assessed. Healthy infants were randomised to receive 2-doses of either: RIX4414 or placebo co-administered with OPV (12 and 16 weeks of age): or RIX4414 or placebo given 15 days after OPV. After vaccination, 56.5-66.7% of RIX4414 and 18.6% of placebo recipients had seroconverted for rotavirus IgA. No significant differences between RIX4414 groups with or without OPV co-administration were observed. No statistically significant differences were observed between groups for polio seroprotection rites. RIX4414 vaccine was immunogenic when co-administered with OPV and did not interfere with OPV seroprotection rates. (C) 2009 Elsevier Ltd. All rights reserved.
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