期刊
VACCINE
卷 27, 期 42, 页码 5806-5815出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.07.063
关键词
Complement; Antibodies; Polysaccharide vaccines
资金
- GlaxoSmithKline
- UK Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Department of Health
- Medical Research Council [G0601617] Funding Source: researchfish
- MRC [G0601617] Funding Source: UKRI
Immunogenicity of 12 capsular polysaccharides (CPS) from Streptococcus pneumoniae did not correlate with pre-existing levels of natural IgM anti-CPS antibodies in mice. Immunization of mice with individual CPS, with the exception of type 14 (the only neutral CPS tested), increased serum IgM that also bound other CPS serotypes independent of structural similarity or commonly known contaminants. Surprisingly only IgM response to type 4 (which has a small immunodominant epitope) was dependent on either complement C3 or complement receptors CD35/CD21. IgG anti-CPS responses were infrequently induced, but critically dependent on complement. Our results have clarified the role of complement in the induction of IgM and IgG anti-CPS antibody responses in mice and have implications for CPS vaccine development. (C) 2009 Elsevier Ltd. All rights reserved.
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