期刊
VACCINE
卷 27, 期 44, 页码 6166-6178出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.08.021
关键词
T cells; Cytotoxic; Vaccination; Cell differentiation
资金
- RIS
- FIS
- FIPSE
- Spanish Ministry of Health
- Abbott Laboratories
- Boehringer Ingelheim
- Bristol Myers Squibb
- GlaxoSmithKline
- Merck Sharp
- Dohme and Roche
- ORVACS [SAF 05/05566, FIS 04/0503, FIS P1050058, FIT 090100-2005-9, FIS PI050265, FIS P1061259, FIS P107/0291]
- Fundacio Privada Clinic per la Recerca BioWdica, Spanish Health Department [FIS 03/00072]
- [SAF 01/2591]
A decrease in HIV-1 specific CD8 T-cell responses associated with a partial control of viral replication occurred in 12 HIV-1-infected patients during autologous dendritic cells vaccination. HIV CD8 T cells were detected in 6/10 patients during immunizations, increasing after HAART discontinuation in 3 of them. Tet+ CD8 cells mainly had an effector phenotype (CD45RA-/+ CCR7- and CD28- and Perf+/-) and maintained IFN-gamma release throughout follow-up. By contrast, patients with CD45RA-/+ CCR7+ Perf+ HIV-specific cells showed a decrease in peptide-specific IFN-gamma production during vaccinations while levels were recovered when off HAART. No major mutations in either Gag p24 and p17 immunodominant epitopes were observed that might have explained the impaired CD8+ T-cell responses. Taken together, heterogeneity in the maturation status of HIV-specific CD8 T cells may be partially involved in the drop of peptide-specific IFN-gamma production during immunizations. (C) 2009 Elsevier Ltd. All rights reserved.
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