期刊
VACCINE
卷 27, 期 40, 页码 5513-5518出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.06.091
关键词
Invasive pneumococcal diseases; Serotype 19A; Invasive potential
资金
- Centers for Disease Control, Taiwan [DOH96-DC-1017]
We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged <= 5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A. which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6: 95% Cl, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged <= 5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged >= 65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed. (C) 2009 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据