期刊
VACCINE
卷 27, 期 27, 页码 3553-3560出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.03.063
关键词
Streptococcus pneumoniae; Invasive disease; Conjugate vaccine; Serotype changes; Antimicrobials; Canada
资金
- Alberta Health and Wellness
- National Microbiology Laboratory, Winnipeg, Manitoba
Alberta, Canada introduced the Streptococcus pneumoniae seven valent conjugate vaccine (PCV7) program for children less than 2 years of age in September 2002. We determined the rates of invasive pneumococcal disease in Alberta, Canada 2 years pre- and 4 years post-PCV7 introduction (2000-2006) as well as the rates of antibiotic resistance and serotype distribution in this same time period. Overall, PCV7 serotypes decreased 61% from 2000 to 2006. The greatest decrease in incidence of invasive pneumococcal disease occurred in children less than 2 years of age declining from a high of 96.7/100,000 (2000) to 25.8/100,000 (2006) (P<0.0001). Non-susceptibility of S. pneumoniae isolates to penicillin dropped significantly from 14% in 2000 to 4.6% in 2006 (P<0.0001). Non-susceptible erythromycin isolates also decreased from 8.8% (2000) to 5.8% (2006) (P=0.13). The introduction of PCV7 in Alberta, Canada has decreased the incidence of invasive pneumococcal disease in Alberta as well as resulting in a decrease in antibiotic resistance over this same time frame, principally for penicillin resistance. (C) 2009 Elsevier Ltd. All rights reserved.
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