期刊
VACCINE
卷 27, 期 25-26, 页码 3306-3312出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.01.090
关键词
HIV; Vaccination; Clinical trial
A randomized, double blind, placebo-controlled phase I vaccine trial based on the native Tat protein was conducted in HIV-infected asymptomatic individuals. The vaccine was administered five times subcute with alum or intradermally without adjuvant at 7.5 mu g, 15 mu g or 30 mu g doses, respectively. The Tat vaccine was well tolerated both locally and systemically and induced and/or maintained Tat-specific T helper (Th)-1 T-cell responses and Th-2 responses in all subjects with a wide spectrum of functional anti-Tat antibodies, rarely seen in HIV-infected subjects. The data indicate the achievement of both the primary (safety) and secondary (immunogenicity) endpoints of the study. (C) 2009 Elsevier Ltd. All rights reserved.
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