期刊
VACCINE
卷 27, 期 50, 页码 6967-6973出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.09.073
关键词
BCG vaccine; Adverse events; Children
资金
- Afssaps
- ACTIV
In a 12-month cohort follow-up study of 2435 children vaccinated in 2007 by Statens Serum Institute BCG strain (BCG SSI (R)), 17.8% had an adverse event (AE): erythema 12.4%, induration 12.2%, abscesses 2.5%, ulceration 0.9%, lymphadenitis 0.1%. The factors associated with a lower risk of AE were: age at vaccination <1 year compared to age >1 year (OR= 0.35 [0.2-0.6] forage <28 days, 0.29 [0.2-0.42] for age 29 days to 2 months, and 0.53 [0.37-0.74] for age 3-11 months), a visible papule (OR= 0.48 [0.36-0.63]), and a low vaccine dose (OR= 0.42 [0.31-0.58]). AE to BCG SSI (R) vaccination were frequent but rarely severe. (C) 2009 Elsevier Ltd. All rights reserved.
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