期刊
VACCINE
卷 26, 期 39, 页码 5046-5057出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.035
关键词
PLGA; lipid A and melanoma
资金
- Canadian Health Institute of Research [MOP 42407]
- Natural Sciences and Engineering Council of Canada [STPGP 336986]
The purpose of this study was to evaluate the efficacy of poly(lactic-co-glycolic acid) (PLGA)-based vaccines in breaking immunotolerance to cancer-associated self-antigens. Vaccination of mice bearing melanoma B16 tumors with PLGA nanoparticles (NP) co-encapsulating the poorly immunogenic melanoma antigen, tyrosinase-related protein 2 (TRP2), along with Toll-like receptor (TLR) ligand (7-acyl lipid A) was examined. Remarkably, this vaccine was able to induce therapeutic anti-tumor effect. Activated TRP2-specific CD8 T cells were capable of interferon (IFN)-gamma secretion at lymph nodes and spleens of the vaccinated mice. More importantly, TRP2/7-acyl lipid A-NP treated group has shown immunostimulatory mileu at the tumor microenvironment, as evidenced by increased level of pro-inflammatory cytokines compared to control group. These results support the potential use of PLGA nanoparticles as competent carriers for future cancer vaccine formulations. (C) 2008 Elsevier Ltd. All rights reserved.
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