期刊
VACCINE
卷 26, 期 -, 页码 D31-D34出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.078
关键词
influenza; Vaccine strain selection; Seasonal influenza viruses
资金
- NIH Director's Pioneer Award [DP1-OD000490-01]
- NIAID-NIH [HHSN266200700010C]
- De Nederlandse Organisatie voor Wetenschappelijk Onderzoek Netherlands Influenza Vaccine Research Centre
- Australian Government Department of Health and Ageing
- The Medical Research Council (UK)
- Medical Research Council [MC_U117512723] Funding Source: researchfish
- MRC [MC_U117512723] Funding Source: UKRI
Annual influenza epidemics in humans affect 5-15% of the population, causing an estimated half million deaths worldwide per year [Stohr K. Influenza-WHO cares. Lancet Infectious Diseases 2002;2(9):517]. The virus can infect this proportion of people year after year because the virus has an extensive capacity to evolve and thus evade the immune response. For example, since the influenza A(H3N2) subtype entered the human population in 1968 the A(H3N2) component of the influenza vaccine has had to be updated almost 30 times to track the evolution of the viruses and remain effective. The World Health Organization Global Influenza Surveillance Network (WHO GISN) tracks and analyzes the evolution and epidemiology of influenza viruses for the primary purpose of vaccine strain selection and to improve the strain selection process through studies aimed at better understanding virus evolution and epidemiology. Here we give an overview of the strain selection process and outline recent investigations into the global migration of seasonal influenza viruses. (c) 2008 Published by Elsevier Ltd.
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