期刊
VACCINE
卷 26, 期 41, 页码 5321-5330出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.06.101
关键词
Influenza; Vaccination; Modelling
资金
- UK Department of Health
There is increasing interest in routine vaccination of children against influenza. We use an age-structured model to demonstrate that the long-term incidence of influenza A could decrease by 11-21% in the overall population by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through targeting those aged 6 to <60 months and 6 months to 16 years, respectively. The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively. These results are sensitive to assumptions about contact patterns and several parameters, including the vaccine efficacy among those aged <24 months, require further study. Consistently high levels of vaccination coverage among pre-school children has the potential to bring benefits to both those vaccinated and the community. (C) 2008 Published by Elsevier Ltd.
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