期刊
VACCINE
卷 26, 期 35, 页码 4602-4607出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.05.087
关键词
CRM197; Haemophilus influenzae type b; conjugate vaccine
资金
- Wyeth Vaccine Research
CRM197 is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria toxoid/tetanus toxoid/acellular pertussis vaccine (DTaP) received either diphtheria CRM197-based Haemophilus influenzae type b conjugate vaccine (HbOC) or HbOC and a diphtheria CRM197-based combination 9-valent pneumococcal conjugate vaccine/meningococcal group C conjugate vaccine. Administration of conjugate vaccines with CRM197 carrier protein load > 50 mu g did not reduce response to CRM197 conjugate vaccines or immunogenicity to immunologically cross-reactive diphtheria toxoid. (c) 2008 Elsevier Ltd. All rights reserved.
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