期刊
VACCINE
卷 26, 期 29-30, 页码 3655-3661出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.04.070
关键词
probiotic Lactobacillus; gnotobiotic pigs; B and T cell immune responses to rotavirus vaccine
资金
- NCCIH NIH HHS [1R21AT002524, R21 AT002524, R21 AT002524-02] Funding Source: Medline
- NIAID NIH HHS [R01 AI033561-11, R01 AI033561, R01AI033561] Funding Source: Medline
We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-gamma producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing antibody titers compared to the AttHRV vaccinated pigs without LA colonization. These findings suggest that L. acidophilus has significant immunopotentiating effects and may be used as a safe oral adjuvant for rotavirus vaccines in neonates. (C) 2008 Elsevier Ltd. All rights reserved.
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