期刊
VACCINE
卷 26, 期 14, 页码 1737-1741出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.01.048
关键词
hepatitis A vaccine; effectiveness; herd immunity
Aim: To investigate the impact of a mass hepatitis A vaccination programme in preadolescents seven years after introduction in terms of its effectiveness and the prevented fraction. Setting: The age distribution of notified cases and incidence rates in Catalonia (Spain) in the periods before (1992-1998) and after (1999-2005) introduction of the vaccination programme were compared. Main results: The incidence rates in the whole population were 5.51 per 100,000 person-years in the 1992-1998 period and 2.98 in the 1999-2005 period. The rate reduction in the 10-19 years age group was 72.43% and was more than 45% in the 5-9 years and 20-29 years age groups. The effectiveness of the vaccination programme was 99.04 (95% CI: 93.11-99.88) and the prevented fraction in the 12-19 years age group was 90.13% (95% Cl: 84.47-90.89). Conclusions: The universal vaccination programme of preadolescents has had an important impact on hepatitis A in Catatonia, not only in vaccinated cohorts but also in non-vaccinated age groups due to a herd immunity effect. (c) 2008 Elsevier Ltd. All. rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据