期刊
VACCINE
卷 26, 期 -, 页码 I34-I39出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.11.059
关键词
Neisseria; Complement; Capsule; Polymorphisms
资金
- MRC
- Wellcome Trust
- Meningococcal Research Foundation
- EMBO
- BBSRC
- MRC [G0601195] Funding Source: UKRI
- Medical Research Council [G0601195] Funding Source: researchfish
Bacterial meningitis and septicaemia is a global health problem often caused by Neisseria meningitidis. The complement system is the most important aspect of host defence against this pathogen, and the critical interaction between the two is influenced by genetic polymorphisms on both the bacterial and the host side: variations of the meningococcus may lead to increased survival in human sera, whereas humans with complement deficiencies are more susceptible to meningococcal infections. Here we discuss the mechanisms of meningococcal resistance against complement-mediated killing and the influence of both bacterial and host genetic factors. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据