Atypical furunculosis vaccines for Atlantic cod (Gadus morhua); vaccine efficacy and antibody responses

Atypical furunculosis caused by atypical Aeromonas salmonicida, is air emerging 1) problem in farming of Atlantic cod (Gadus morhua) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing it) Surface antigens Such as the A-layer protein and lipopolysaccharides (LPS). Except for one of the experimental oil-adjuvanted whole cell vaccines based on various isolates they all resulted in moderate protection. No clear correlation between vaccine efficacies and the A-protein group or LIPS type of the vaccine isolates was revealed, while a Correlation between efficacy and the presence of cross-reacting LIPS-specific antibodies is indicated. (C) 2008 Elsevier Ltd. All rights reserved.