期刊
UROLOGY
卷 76, 期 4, 页码 1007-1011出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urology.2010.02.025
关键词
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资金
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [A090770]
- Korea Health Promotion Institute [A090770] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
OBJECTIVES To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment. METHODS A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated. RESULTS The mean elastic modulus of the regions containing cancer and noncancer was 24.1 +/- 14.5 and 17.0 +/- 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm(3) than in the other tissue. CONCLUSIONS We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score. UROLOGY 76: 1007-1011, 2010. (C) 2010 Elsevier Inc.
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