期刊
UROLOGY
卷 72, 期 2, 页码 247-254出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urology.2008.03.033
关键词
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资金
- NCI NIH HHS [K23 CA122820-02, K23 CA122820, R01 CA218547, P50CA97186, R01 CA158627, R01 CA195505, P50 CA097186] Funding Source: Medline
Direct determination of androgen levels in prostate tissue provides a perspective on the organ that is not available via androgen serum levels. The principle prostatic androgens, primarily dihydrotestosterone (D]IT) and secondarily testosterone, can be readily assayed in quick-frozen prostate biopsy cores or surgical specimens. Such assays have proved important in establishing (1) that DHT is a permissive factor in BPH pathogenesis, (2) a mechanism for the treatment of BPH, (3) an understanding of prostate cancer chemoprevention, (4) an explanation for the 'escape' of prostate cancer from castration therapy, (5) prostate safety of testosterone replacement therapy, and (6) insights into the cause of racial differences of prostate cancer. Future opportunities include clarification of new drug mechanisms for BPH and prostate cancer, as well as a better understanding of the pathogenesis of both, and as an aid in individual patient management, Determination of prostate tissue androgens may soon transition from research toot to clinical test.
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